Lithium triethylborohydride → (3-Bromo-2-chlorophenyl)methanol

Participants

Reaction Steps

To a solution of methyl 3-bromo-2-chlorobenzoate (1.9 g, 7.6 mmol) in THF (30 mL) was added Super Hydride (23 mL, 23 mmol) at 0° C. The reaction was allowed to stir for 16 hours. TLC showed clean reaction. The reaction was diluted with EtOAc, washed with brine, dried over sodium sulfate, and purified by MPLC to furnish (3-bromo-2-chlorophenyl)methariol. LC-MS (IE, m/z): 205 [M-17]+;

Provenance & Evidence