Allyltributylstannane → HCID 67516513, compound

Participants

Reaction Steps

To a flask charged with 5-bromo-4-fluoro-2-benzofuran-1(3H)-one (52 mg, 0.22 mmol) and a stir bar was added allyl tri-n-butyltin (0.10 mL, 0.34 mmol), palladium tetrakis (39 mg, 0.034 mmol), lithium chloride (29 mg, 0.68 mmol), and toluene (5 mL). The mixture was purged three times with nitrogen, and heated to reflux for 4 hours. LC showed formation of the desired product, which was purified by silica gel chromatography to deliver 5-allyl-4-fluoro-2-benzofuran-1(3H)-one. LC-MS (IE, m/z): 193 [M+1]+;

Provenance & Evidence