Hydrochloric Acid → HCID 67517546, compound

Participants

Reaction Conditions

Reaction Steps

In a 15 mL microwave tube, methyl 3-(hydroxymethyl)-4-methylthiophene-2-carboxylate (440 mg, 2.36 mmol, 1.0 eq) was dissolved in THF/MeOH/water (2:1:1, 2 mL). To above solution was added Lithium hydroxide (68 mg, 2.84 mmol). The mixture was heated at 100° C. for 30 min in microwave reactor, neutralized with 1 N HCl, extracted with dichloromethane, washed with brine and water. The organic phase was dried over MgSO4, filtered and concentrated. LC-MS (IE, m/z): 195.3 [M+Na]+; 1H NMR (500 MHz, CD3OD, δ in ppm): 7.25 (114, s), 4.86 (2H, m), 2.28 (3H, s);

Provenance & Evidence