Sulfuric acid magnesium salt (1:1) → HCID 86693005, compound

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Reaction Steps

A mixture of (1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetaldehyde (3.5 g, 20 mmol), Boc-piperazine (3.5 g, 20 mmol) and anhydrous MgSO4(20 g, 166 mmol) in 100 mL of anhydrous DCM were stirred at room temperature over night. The solid was filtered and the solvent was evaporated at reduced pressured to get the crude product. The crude product was purified via column chromatograph to afford tert-butyl 4-[(E)-2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethenyl]piperazine-1-carboxylate. 1H-NMR (400 MHz, CDCl3) δ ppm 7.74 (d, J=8.2 Hz, 1H), 7.29˜7.34 (m, 2H), 6.88 (d, J=13 Hz, 1H), 5.55 (d, J=14 Hz, 1H), 5.25 (s, 2H), 3.49˜3.58 (m, 4H), 3.12˜3.17 (m, 4H), 1.50 (s, 9H).

Provenance & Evidence