Dichloromethane → HCID 67517293, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[(E)-2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethenyl]piperazine-1-carboxylate (1.1 g, 3 mmol) in 30 mL of DCM was added Pd(OAc)2 (100 mg) and was cooled by ice/water. 50 mL of newly prepared CH2N2 solution was added dropwise. The reaction was warmed to room temperature and stirred over night. The solid was filtered off, and the filtrate was evaporated at reduced pressure to get crude product, which was purified via prep-HPLC to afford tert-butyl 4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)cyclopropyl]piperazine-1-carboxylate.

Provenance & Evidence