1,4-Dioxane hydrochloride → HCID 67518204, compound

HRID 2173210Notes

Reaction equation

HRID 2173210 reaction equation
[O:1]=[C:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH:11]3[CH2:13][CH:12]3[N:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)=[CH:10][C:5]=2[CH2:4][O:3]1.Cl.O1CCOCC1>C(Cl)Cl>[N:14]1([CH:12]2[CH2:13][CH:11]2[C:9]2[CH:8]=[CH:7][C:6]3[C:2](=[O:1])[O:3][CH2:4][C:5]=3[CH:10]=2)[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67517293HCID 67517293, compound

Product 1

HCID 67518204HCID 67518204, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl 4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)cyclopropyl]piperazine-1-carboxylate (30 mg, 0.08 mmol) in 5 mL of DCM was added 3 mL of 4N HCl/dioxane, and then the mixture was stirred at room temperature for 2 hours. The solvents was removed off under vacuum to afford 5-[2-(piperazin-1-yl)cyclopropyl]-2-benzofuran-1(3H)-one.

Workup

  1. customThe solvents was removed off under vacuum

Sources & evidence

ORD record
ord-e4f32f9e010c4530ba7ff00d63ac3ad1
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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