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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2173214Generated: November 1, 2026

3-(4-Cyano-3-fluorophenyl)-1-propene → 2-Fluoro-4-[2-(piperazin-1yl)ethyl]benzonitrile

https://huagongshe.com/reaction/2173214

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Cyano-3-fluorophenyl)-1-propeneHCID 24721766—
Reactant2-Methoxy-4-[2-(piperazin-1-yl)ethyl]benzonitrileHCID 67516927—
Product2-Fluoro-4-[2-(piperazin-1yl)ethyl]benzonitrileHCID 67515950—

Reaction Steps

2-Fluoro-4-[2-(piperazin-1yl)ethyl]benzonitrile was prepared from 2-fluoro-4-(prop-2-en-1-yl)benzonitrile (described above) in an analogous fashion to that described for 2-methoxy-4-[2-(piperazin-1-yl)ethyl]benzonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09056859B2
Source datasetuspto-grants-2015_06
ORD IDord-ecfe64f8682642aaa6bf4d175e6fa79f
Source noteuspto-grants-2015_06