Methyl morpholine oxide → HCID 67515717, compound

Participants

Reaction Steps

To a solution of 3-(prop-2-en-1-yl)benzonitrile (3.8 g, 27 mmol) and NMO (10.85 g, 80 mmol) in MeOH/H2O (v/v=3:1, 133 mL) was added OsO4 (600 mg), and then stirred at room temperature for 18 h. The result mixture was concentrated and the residue was dissolved in water and extracted with EtOAc. The organic layers were dried and concentrated, and the residue was purified by a flash column chromatography to afford 3-(2,3-dihydroxypropyl)benzonitrile.

Provenance & Evidence