HCID 67515717, compound → 3-(2-Oxoethyl)benzonitrile
Reaction equation
[OH:1][CH:2](CO)[CH2:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[C:7]#[N:8]>CO.O>[O:1]=[CH:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[C:7]#[N:8]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A solution of 3-(2,3-dihydroxypropyl)benzonitrile (2.7 g, 15.3 mmol) in MeOH/H2O (v/v=3:1, 40 mL) was added NaIO4 at 0° C. and then stirred at 0° C. for 1.5 h. The result mixture was filtered and the filtrate was concentrated to afford 3-(2-oxoethyl)benzonitrile, which was used next step without further purification.
Workup
- filtrationThe result mixture was filtered
- concentrationthe filtrate was concentrated
Sources & evidence
- ORD record
- ord-a3e9ba16a1fe478db9611706db1f8793
- Source dataset
- uspto-grants-2015_06
- Patent number
- US09056859B2
Reaction notes
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