HCID 131732966, compound → HCID 67518394, compound

HRID 2173237Notes

Reaction equation

HRID 2173237 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[N+:14]([C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[CH2:22][CH:21]=[CH:20]2)([O-])=O>CO.[Pd]>[NH2:14][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[CH2:22][CH:21]([N:11]1[CH2:10][CH2:9][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:13][CH2:12]1)[CH2:20]2

Participants

4

Reactant 1

HCID 131732966HCID 131732966, compound

Product 1

HCID 67518394HCID 67518394, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 5-nitro-indene bocpiperazine (0.740 g, 2.13 mmol) in methanol (20 mL) was added Pd/C (0.280 g, 2.63 mmol). The reaction mixture was stirred under H2 for 48 h. When the hydrogenation was complete, the reaction mixture was passed through a pad of Celite® and washed several times with methanol. The collected organics were then concentrated in vacuo and gave the title product. LC/MS: [(M+1)]+=318;

Workup

  1. washwashed several times with methanol
  2. concentrationThe collected organics were then concentrated in vacuo

Sources & evidence

ORD record
ord-fd6a7d34187e4259895c255b047a062c
Source dataset
uspto-grants-2015_06
Patent number
US09056859B2

Reaction notes

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