HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-Oxo-2,3-Dihydro-1H-Indene-4-Carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Indanone, 4-bromo- | HCID 98713 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 1-Oxo-2,3-Dihydro-1H-Indene-4-Carbonitrile | HCID 2751583 | — |
Reaction Conditions
| Temperature | 165 °C |
|---|
Reaction Steps
To a solution of 4-bromo-2,3-dihydro-1H-inden-1-one (1.00 g, 4.74 mmol) in 5 mL of DMF was added Zn(CN)2 (556 mg, 4.74 mmol) and Pd(PPh3)4 (77 mg, 0.14 mmol), and the reaction mixture was stirred under microwave irradiation for 1 h at 165° C. The solvent was removed in vacuum to afford the crude compound, which was purified via column chromatography to afford 1-oxo-2,3-dihydro-1H-indene-4-carbonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056859B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-cf220989844747f688423c3f1896fa45 |
| Source note | uspto-grants-2015_06 |