N,O-Dimethylhydroxylamine → HCID 86693011, compound

Participants

Reaction Steps

A mixture of 6-fluoro-5-iodo-3,4-dihydro-1H-isochromene-1-carboxylic acid (1.32 g, 4 mmol) and CDI (690 mg, 4.9 mmol) in 50 mL of dry DCM was stirred at r.t. for 3 hrs and then O,N-dimethyl-hydroxylamine (500 mg, 5.1 mmol) was added. The result mixture was stirred oversight. The solvents were removed under vacuum, and the residue was purified via column chromatograph to afford 6-fluoro-5-iodo-N-methoxy-N-methyl-3,4-dihydro-1H-isochromene-1-carboxamide.

Provenance & Evidence