Diisobutylaluminum hydride → HCID 87429363, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 6-fluoro-5-iodo-N-methoxy-N-methyl-3,4-dihydro-1H-isochromene-1-carboxamide (700 mg, 0.2 mmol) in 30 mL of anhydrous THF was cooled to −30° C. and then DIBAL-H (0.3 mmol) was added. The mixture was stirred at −30° C. for 1 hours. The reaction was quenched with water, and extracted with DCM. The orgainc layer was washed with brine, dried over anhydrous sodium sulfate and concentrated. The residue was used for the next step without purification.

Provenance & Evidence