Nitrogen → HCID 67518235, compound

Participants

Reaction Steps

A solution of tert-butyl 4-[(6-fluoro-5-iodo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate (200 mg, 0.42 mmol), Pd(PPh3)4 (200 mg) and Zn(CN)2 (300 mg, 2.6 mmol) in 20 mL of anhydrous DMF was to 110° C. at N2 atmosphere for 2 hours. The reaction was cooled to room temperature, diluted with EtOAc and washed with water and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated. The residue was purified with prep-TLC to afford tert-butyl 4-[(5-cyano-6-fluoro-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate.

Provenance & Evidence