1,4-Dioxane hydrochloride → HCID 67518007, compound

Participants

Reaction Steps

A solution of tert-butyl 4-[(5-cyano-6-fluoro-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate (110 mg, 0.29 mmol) in 10 mL of DCM was added 3 mL of 4N HCl/dioxane, then sirred at room temperature for 2 hours. The solvents was removed off under vacuum to afford 6-fluoro-1-(piperazin-1-ylmethyl)-3,4-dihydro-1H-isochromene-5-carbonitrile hydrochloride. 1H-NMR (400 MHz, MeOD) δ ppm 7.63˜7.66 (m, 1H), 7.25˜7.29 (m, 1H), 5.33˜5.30 (m, 1H), 4.25˜4.30 (in, 1H), 3.87˜3.97 (m, 2H), 3.72˜3.83 (m, 3H), 3.58˜3.68 (m, 6H), 3.07˜3.17 (m, 2H).

Provenance & Evidence