Triethylamine → HCID 67517382, compound

Participants

Reaction Conditions

Reaction Steps

A solution of tert-butyl 4-[(7-carbamoyl-2,3-dihydro-1-benzofuran-3-yl)methyl]piperazine-1-carboxylate in DCM (80 mg, 0.22 rnmol) was added Et3N (60 mg, 0.59 mmol). The solution was cooled to 0° C. and TFAA (60 mg, 0.29 mmol) was added dropwise under nitrogen. After 4 hours stirring at room temperature, the solvents were removed under vacuum to give the crude product tert-butyl 4-[(7-cyano-2,3-dihydro-1-benzofuran-3-yl)methyl]piperazine-1-carboxylate (66 g, yield 87%) which was used for next step without purification.

Provenance & Evidence