HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(6-nitropyridin-3-yl)acetate → Ethyl 2-(6-aminopyridin-3-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(6-nitropyridin-3-yl)acetate | HCID 21300451 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(6-aminopyridin-3-yl)acetate | HCID 67143734 | — |
Reaction Steps
A suspension of 10% Pd on carbon (9.21 g, 8.66 mmol) in a solution of the ethyl (6-nitropyridin-3-yl)acetate (36.4 g, 173 mmol) in EtOH (364 mL) was hydrogenated at 20 psi and 25° C. for 2 h. The suspension was filtered through Solka Floc eluting with 200 mL EtOH. The filtrate was concentrated and solvent switched with EtOAc, then concetrated to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056859B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-ba8e3d423875473dad706205271d7426 |
| Source note | uspto-grants-2015_06 |