Hydrogen chloride-ethyl acetate → 1-(piperazin-1-yl)-2-[6-(1H-tetrazol-1-yl)pyridin-3-yl]ethanone hydrochloride

Participants

Reaction Steps

A mixture of tert-butyl 4-{[6-(1H-tetrazol-1-yl)pyridin-3-yl]acetyl}piperazine-1-carboxylate (60 mg, 0.16 mmol) in HCl/EtOAc (3 mL) was stirred for 3 hours at room temperature. The reaction mixture was concentrated under reduce pressure to give 1-(piperazin-1-yl)-2-[6-(1H-tetrazol-1-yl)pyridin-3yl]ethanone hydrochloride. MS m/z 274 (M+1)+. 1H-NMR (400 MHz, MeOD) δ 9.89 (s, 1H), 8.46 (s, 1H), 8.05˜8.07 (m, 1H), 7.99˜8.00 (m, 1H), 3.99 (s, 2H), 3.85˜3.92 (m, 4H), 3.24˜3.30 (m, 4H).

Provenance & Evidence