HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane → 1-[(1S,4S)-2,5-Diazabicyclo[2.2.1]hept-2-yl]-2-[6-(1H-tetrazol-1-yl)pyridin-3-yl]ethanone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane | HCID 11521263 | — |
| Reactant | [6-(1H-Tetrazol-1-yl)pyridine-3-yl]acetic acid | HCID 66524945 | — |
| Reactant | 1-(piperazin-1-yl)-2-[6-(1H-tetrazol-1-yl)pyridin-3-yl]ethanone hydrochloride | HCID 67517149 | — |
| Product | 1-[(1S,4S)-2,5-Diazabicyclo[2.2.1]hept-2-yl]-2-[6-(1H-tetrazol-1-yl)pyridin-3-yl]ethanone hydrochloride | HCID 86693015 | — |
Reaction Steps
1-[(1S,4S)-2,5-Diazabicyclo[2.2.1]hept-2-yl]-2-[6-(1H-tetrazol-1-yl)pyridin-3-yl]ethanone hydrochloride was prepared in two steps starting from [6-(1H-tetrazol-1-yl)pyridin-3-yl]acetic acid and commercially available tert-butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate in an analogous fashion as described for the synthesis of 1-(piperazin-1-yl)-2-[6-(1H-tetrazol-1-yl)pyridin-3-yl]ethanone hydrochloride. MS m/z 286 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056859B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-25ec77aa6b6e4e449b5d4ffd2f0a18cf |
| Source note | uspto-grants-2015_06 |