HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2173328Generated: October 31, 2026
Tert-butyl ethyl (5-nitropyrazin-2-yl)propanedioate → Ethyl 2-(5-nitropyrazin-2-yl)acetate
https://huagongshe.com/reaction/2173328
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tert-butyl ethyl (5-nitropyrazin-2-yl)propanedioate | HCID 86693017 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | Ethyl 2-(5-nitropyrazin-2-yl)acetate | HCID 77230650 | — |
Reaction Steps
A mixture of tert-butyl ethyl (5-nitropyrazin-2-yl)propanedioate (10.7 g, 34.4 mmol) in 30 mL of TFA and 30 mL DCM was stirred at 35° C. for 3 hours before concentrated to dryness. The residue was dissolved in 200 mL of EtOAc and washed with water (25 mL) and brine (25 mL), dried over anhydrous Na2SO4 and concentrated to afford ethyl (5-nitropyrazin-2-yl)acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09056859B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-3e5d3563466f481f81fe9520e2bfde19 |
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| Source note | uspto-grants-2015_06 |
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