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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2173334Generated: October 30, 2026

2-(4-Cyano-2-fluoro-5-methoxyphenyl)acetic acid → 5-Fluoro-2-methoxy-4-[2-oxo-2-(piperazin-1-yl)ethyl]benzonitrile hydrochloride

https://huagongshe.com/reaction/2173334

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(4-Cyano-2-fluoro-5-methoxyphenyl)acetic acidHCID 66524893—
Reactant1-(piperazin-1-yl)-2-[6-(1H-tetrazol-1-yl)pyridin-3-yl]ethanone hydrochlorideHCID 67517149—
Product5-Fluoro-2-methoxy-4-[2-oxo-2-(piperazin-1-yl)ethyl]benzonitrile hydrochlorideHCID 86693018—

Reaction Steps

5-Fluoro-2-methoxy-4-[2-oxo-2-(piperazin-1-yl)ethyl]benzonitrile hydrochloride was prepared in two steps from (4-cyano-2-fluoro-5-methoxyphenyl) acetic acid in an analogous fashion to that described for the synthesis of 1-(piperazin-1-yl)-2-[6-(1H-tetrazol-1-yl)pyridin-3-yl]ethanone hydrochloride. MS m/z 278 (M+1)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09056859B2
Source datasetuspto-grants-2015_06
ORD IDord-64c4d6e6520f44bfa431d227f8797d96
Source noteuspto-grants-2015_06