Trifluoromethanesulfonic anhydride → 4-((Methoxycarbonyl)methyl)-5-chloro-2-methoxyphenyl trifluoromethanesulfonate

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Reaction Steps

To a solution of methyl (2-chloro-4-hydroxy-5-methoxyphenyl)acetate (570 mg, 2.468 mmol) in 10 mL of pyridine was added Tf2O (853 mg, 2.962 mmol) dropwise at 0° C. The resulting mixture was stirred at rt overnight and concentrated to dryness. The residue was dissolved in EtOAc (50 mL), washed with 1 N HCl (50 mL), brine (50 mL), dried over anhydrous Na2SO4 and concentrated to give methyl(2-chloro-5-methoxy-4-{[(trifluoromethyl)sulfonyl]oxy}phenyeacetate.

Provenance & Evidence