2-(4-Nitrophenyl)propionic acid → 4-Aminohydratropic acid

Participants

Reaction Steps

2-(4-nitrophenyl) propionic acid (5 g, 25.6 mmol) was dissolved in ethyl acetate (50 ml) and palladium on carbon (1 g, 9.40 mmol) was added then stirred under hydrogen balloon overnight. The product precipitated out. Added methanol to dissolved product then filtered off the palladium catalyst. The filtrate was concentrated and the residue was triturated with ethyl acetate to yield 2-(4-aminophenyl) propionic acid. LC-MS (IE, m/z): 166 [M+1]+;

Provenance & Evidence