HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Tetrazol-1-yl-phenyl)-acetic acid → 1-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Tetrazol-1-yl-phenyl)-acetic acid | HCID 841658 | — |
| Reactant | 8-Boc-3,8-diaza-bicyclo(3.2.1)octane | HCID 15740908 | — |
| Reactant | 1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride | HCID 67517236 | — |
| Product | 1-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone | HCID 67517231 | — |
Reaction Steps
1-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone was prepared in an analogous fashion as described above in the synthesis of 1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride starting from [4-(1H-tetrazol-1-yl)phenyl]acetic acid and tert-butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate. LC/MS: [(M+1)]+=299.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056859B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-b1a123e8dd024c8fa18c552846702be7 |
| Source note | uspto-grants-2015_06 |