HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Tetrazol-1-yl-phenyl)-acetic acid → 1-(2,5-Diazabicyclo[2.2.2]oct-2-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Tetrazol-1-yl-phenyl)-acetic acid | HCID 841658 | — |
| Reactant | Tert-butyl 2,5-diazabicyclo(2.2.2)octane-2-carboxylate | HCID 56973608 | — |
| Reactant | 1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride | HCID 67517236 | — |
| Product | 1-(2,5-Diazabicyclo[2.2.2]oct-2-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride | HCID 86693019 | — |
Reaction Steps
1-(2,5-Diazabicyclo[2.2.2]oct-2-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride was prepared in an analogous fashion as described above in the synthesis of 1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride starting from [4-(1H-tetrazol-1-yl)phenyl]acetic acid and commercially available tert-butyl 2,5-diazabicyclo[2.2.2]octane-2-carboxylate. LC/MS: [(M+1)]+=299
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056859B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-901a97b56d444b09931b15ed500bd6d8 |
| Source note | uspto-grants-2015_06 |