Hydrochloric Acid → HCID 67517721, compound

Participants

Reaction Steps

1-(3-Benzyl-3,8-diazabicyclo[3.2.1]oct-8-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone (580 mg, 1.49 mmol) was dissolved in ethanol (20 mL), concentrated HCl solution was added (37%, 2.0 mL, 24.4 mmol), followed by palladium on carbon (200 mg). The mixture was degassed and stirred under hydrogen gas at room temperature overnight. The reaction mixture was filtered through a Celite® plug and the filtrate was concentrated. The product was partitioned between DCM and saturated sodium bicarbonate solution, then the organic layer was dried over MgSO4. Purification by MPLC eluting with 10% methanol in DCM afforded the title compound. LC/MS: [(M+1)]+=299.

Provenance & Evidence