HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2-(4-Amino-2,5-difluorophenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 2-(2,5-Difluoro-4-nitrophenyl)acetic Acid | HCID 67515939 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(4-Amino-2,5-difluorophenyl)acetic acid | HCID 67515913 | — |
Reaction Steps
To a solution of (2,5-difluoro-4-nitrophenyl)acetic acid (440 mg, 2.03 mmol) in 20 ml of EtOAc was added HOAc (121 mg, 2.03 mmol) and 200 mg of Pd/C was stirred at room temperature under H2 atmosphere for 3 hours. The reaction mixture was filtrated and concentrated to give (4-amino-2,5-difluorophenyl)acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056859B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-7f0df05282c4479c9c1bab06fb4cea00 |
| Source note | uspto-grants-2015_06 |