HCID 67516104, compound → HCID 67516005, compound

Participants

Reaction Steps

A solution of [2-(methylsulfanyl)-4-nitrophenyl]acetic acid (230 mg, 1.0 mmol) in 10 mL of water and 0.6 mL of NH3.H2O was added a solution of FeSO4.7H2O (2.25 g, 8.1 mmol) in 10 mL of water and another 1.6 mL of NH3.H2O were added dropwise. The mixture was stirred at 60˜80° C. overnight. The mixture was filtered and the filtrate was acidified to pH 4˜5 with HOAc. Extracted with EtOAc and the combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated to afford [4-amino-2-(methylsulfanyl)phenyl]acetic acid.

Provenance & Evidence