Lithium hydroxide, monohydrate → HCID 67517159, compound

Participants

Reaction Steps

A solution of methyl [3-iodo-4-(1H-tetrazol-1-yl)phenyl]acetate (1 g, 2.9 mmol) in a co-solution 50 mL of THF/methanol/water (2:2:1) was added added LiOH.H2O (0.6 g, 14.5 mmol), and the mixture was stirred at ambient temperature over night. Concentrated and the residue was dissolved in water and then adjusted pH=3 with 2N HCl. Extracted with DCM, and orgianc layers were washed with water, brine and dried over anhydrous sodium sulfate, concentrated to get crude product [3-iodo-4-(1H-tetrazol-1-yl)phenyl]acetic acid, which was used for the next step without purification.

Provenance & Evidence