HuagongsheHuagongshe Chemistry Print Report · For research reference only
Di-tert-butyl malonate → 4-Cyano-5-fluoro-2-methoxyphenylacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Di-tert-butyl malonate | HCID 68324 | — |
| Reactant | 2-(4-Cyano-2-fluoro-5-methoxyphenyl)acetic acid | HCID 66524893 | — |
| Reactant | 2,4-Difluoro-5-methoxybenzonitrile | HCID 67517101 | — |
| Product | 4-Cyano-5-fluoro-2-methoxyphenylacetic acid | HCID 67516499 | — |
Reaction Steps
(4-Cyano-5-fluoro-2-methoxyphenyl)acetic acid was prepared in a similar fashion to the previously described synthesis of (4-cyano-2-fluoro-5-methoxyphenyl)acetic acid starting from di-tert-butyl malonate and 2,4-difluoro-5-methoxybenzonitrile. LC-MS (IE, m/z): 208 [M−1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056859B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-22f53cdc201e435eb6f143060188f4b7 |
| Source note | uspto-grants-2015_06 |