Trifluoroacetic acid → HCID 131732971, compound

Participants

Reaction Steps

In a round bottom flask charged with stirring bar, tert-butyl (±)5-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-2,5-diazabicyclo[4.1.0]heptane-2-carboxylate (502 mg, 1.292 mmol) was dissolved in DCM (5 mL) and was treated with TFA (2 mL, 26.0 mmol) at room temperature for 3 hours. Then solvent was removed on rotavapor. Residue was re-dissolved in small amount of DCM and evaporated to take out remained TFA. Then it was dried on high vacuum pump for 4 hours to remove extra TFA. Without further purification, crude product was used to make ROMK inhibitors. LC/MS: (M+1)+=289.

Provenance & Evidence