4-[(4-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperazin-1-yl)methyl]-3,4-dihydro-2H-chromene-8-carbonitrile → 4-({4-[(1-Oxo-1,3-dihydro-2-benzofuran-5-yl)acetyl]piperazin-1-yl}methyl)-3,4-dihydro-2H-chromene-8-carbonitrile

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4-({4-[(1-Oxo-1,3-dihydro-2-benzofuran-5-yl)acetyl]piperazin-1-yl}methyl)-3,4-dihydro-2H-chromene-8-carbonitrile was prepared in an analogous fashion to that described for the synthesis of 4-[(4-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperazin-1-yl)methyl]-3,4-dihydro-2H-chromene-8-carbonitrile above starting from 4-formyl-3,4-dihydro-2H-chromene-8-carbonitrile and 5-[2-oxo-2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one. 1H-NMR (400 MHz, CDCl3) δ ppm 7.85 (d, J=7.8 Hz, 1H), 7.31˜7.38 (m, 4H), 6.8 (t, J=7.8 Hz, 1H), 5.24 (s, 2H), 4.15˜4.45 (m, 2H), 3.8 (s, 2H), 3.4˜3.73 (m, 4H), 2.88˜2.95 (m, 1H), 2.3˜2.52 (m, 6H), 1.97˜2.1 (m, 2H).

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