Dichloromethane → HCID 67517817, compound

Participants

Reaction Steps

A solution of 5-[2-(4-{[2-ethenyl-4-(1H-tetrazol-1-yl)phenyl]acetyl}piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one (40 mg, 0.08 mmol) in 5 mL of DCM was added a solution of CH2N2 in 2 mL Et2O and Pd(OAc)2 (10 mg) at 0° C. The mixture was stirred at room temperature overnight. The reaction mixture was filtrated and purified by prep-TLC to afford 5-[2-(4-{[2-cyclopropyl-4-(1H-tetrazol-1-yl)phenyl]acetyl}piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one. 1H-NMR (400 MHz, CDCl3) δ ppm 9.0 (s, 1H), 7.76˜7.78 (m, 1H), 7.26˜7.4 (in, 5H), 5.22 (s, 2H), 3.88 (s, 2H), 3.49˜3.66 (m, 4H), 2.83˜2.93 (m, 2H), 2.6˜2.62 (m, 2H), 2.38˜2.48 (m, 4H), 2.0 (s, 1H), 0.94˜0.98 (m, 2H), 0.66˜0.68 (m, 2H).

Provenance & Evidence