反应详情

6-(4-{[4-(1H-Tetrazol-1-yl)phenyl]acetyl}piperazin-1-yl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile was prepared in an analogous fashion to that described above for the synthesis of 5-[2-(4-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperazin-1-yl)propyl]-2-benzofuran-1(3H)-one starting from 1-(piperazin-1-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone hydrochloride and known compound 6-oxo-5,6,7,8-tetrahydronaphthalene-2-carbonitrile (Ralf Heim, et al. J. Med. Chem. 2008, 51(16), 5064-5074). LC/MS: [(M+1)]+=428.