反应详情

5-Fluoro-2-methoxy-4-(2-oxo-2-{4[(3-oxo-3,6,8,9-tetrahydro-1H-furo[3,4-f]isochromen-6-yl)methyl]piperazin-1-yl}ethyl)benzonitrile was prepared from (3-oxo-3,6,8,9-tetrahydro-1H-furo[3,4-f]isochromen-6-yl)methyl4-methylbenzenesulfonate and 5-fluoro-2-methoxy-4-[2-oxo-2-(piperazin-1-yl)ethyl]benzonitrile in an analogous fashion to that described above for the synthesis of 6-[(4-{[4-(1H-tetrazol-1-yl)phenyl]acetyl}piperazin-1-yl)methyl]-8,9-dihydro-1H-furo[3,4-f]isochromen-3(6H)-one. MS m/e 480 (M+1)+.