反应详情

5-Amino-6-chloropyrimidine-4-thiol (A-3) (14.0 g, 86.9 mmol) is dissolved in triethoxymethane (180 mL), and the resulting mixture is stirred at reflux for 3 h. The mixture is allowed to cool to RT and then concentrated in vacuo. The residue is purified by flash column chromatography on silica gel (5-10% ethyl acetate-petro ether) to afford the product, 7-chlorothiazolo[5,4-d]pyrimidine (A-4).

1. temperatureat reflux for 3 h
2. concentrationconcentrated in vacuo
3. customThe residue is purified by flash column chromatography on silica gel (5-10% ethyl acetate-petro ether)