HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-2-(chloromethyl)-3-fluorobenzene → HCID 71558359, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-2-(chloromethyl)-3-fluorobenzene | HCID 108675 | — |
| Reactant | 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine | HCID 71558205 | — |
| Reactant | HCID 178441789 | HCID 178441789 | — |
| Product | HCID 71558359 | HCID 71558359 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 61), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 1-chloro-2-(chloromethyl)-3-fluorobenzene and isolated as white solid (6.8 mg, 39%). MS(m/e): 425.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056866B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-77765c1fdf1249308271805a77f3a788 |
| Source note | uspto-grants-2015_06 |