5-(Chloromethyl)-3-methyl-1,2,4-oxadiazole → 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-3-(3-methyl-[1,2,4]oxadiazol-5-ylmethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

Participants

Reaction Steps

In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-ethyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 61), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 5-(chloromethyl)-3-methyl-1,2,4-oxadiazole and isolated as light-yellow gum. MS(m/e): 379.3 (MH+).

Provenance & Evidence