HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2173609Generated: October 27, 2026
Trifluoroacetic acid → HCID 178441791, compound
https://huagongshe.com/reaction/2173609
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | (S)-1-[5-tert-Butyl-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-pyrrolidin-3-ol | HCID 86683311 | — |
| Product | HCID 178441791 | HCID 178441791 | — |
Reaction Steps
A mixture of (S)-1-[5-tert-Butyl-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-pyrrolidin-3-ol (example 106) and triethylsilane in TFA was heated to 70° C. for 22 h and evaporated to dryness. The residue was used without further purification in the consecutive step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09056866B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-1ebeac5b67944de8ad0d3c0b0e3455cd |
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| Source note | uspto-grants-2015_06 |
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