5-tert-Butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine → HCID 86683366, compound

HRID 2173639Notes

Reaction equation

HRID 2173639 reaction equation
C(C1N=C(N2CCOCC2)[C:8]2N=N[N:11]([CH2:14][C:15]3[CH:20]=CC=C[C:16]=3Cl)[C:9]=2N=1)(C)(C)C.[C:28]([C:32]1[N:33]=[C:34](Cl)[C:35]2[N:40]=[N:39][N:38]([CH2:41][C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=3[Cl:48])[C:36]=2[N:37]=1)([CH3:31])([CH3:30])[CH3:29].CC1(C)CCNC1>>[C:28]([C:32]1[N:33]=[C:34]([N:11]2[CH2:9][CH2:8][C:15]([CH3:16])([CH3:20])[CH2:14]2)[C:35]2[N:40]=[N:39][N:38]([CH2:41][C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=3[Cl:48])[C:36]=2[N:37]=1)([CH3:31])([CH3:30])[CH3:29]

Participants

4

Reactant 3

HCID 14339535-tert-Butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidineHCID 149492113,3-DimethylpyrrolidineHCID 866832845-tert-butyl-7-chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

Product 1

HCID 86683366HCID 86683366, compound

Procedure

In analogy to the procedure described for the synthesis of 5-tert-butyl-3-(2-chlorobenzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 1, step c), the title compound was prepared from 5-tert-butyl-7-chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 3,3-dimethylpyrrolidine. MS(m/e): 399.4 (MH+).

Sources & evidence

ORD record
ord-5c5e69df99414869b5d934c087d7e5c8
Source dataset
uspto-grants-2015_06
Patent number
US09056866B2

Reaction notes

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