Morpholine → HCID 71533265, compound

HRID 2173707Notes

Reaction equation

HRID 2173707 reaction equation
[N:1]1[NH:2][C:3]([NH:6][C:7]([C:9]2[C:14]([NH2:15])=[N:13][C:12]([C:16]([F:19])([F:18])[F:17])=[C:11](Br)[N:10]=2)=[O:8])=[CH:4][CH:5]=1.[NH:21]1[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>>[N:1]1[NH:2][C:3]([NH:6][C:7]([C:9]2[C:14]([NH2:15])=[N:13][C:12]([C:16]([F:19])([F:18])[F:17])=[C:11]([N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)[N:10]=2)=[O:8])=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 71533263HCID 71533263, compound

Product 1

HCID 71533265HCID 71533265, compound

Procedure

A mixture comprising 3-amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid (2H-pyrazol-3-yl)-amide (Ex. 6) (42 mg, 0.120 mmol) and morpholine (1 ml, 11.3 mmol) was heated at 100-140° C. using microwave for 8 hours and 15 minutes. The reaction mixture was concentrated in vacuo and purification of the residue by preparative LC-MS afforded the title compound as a yellow solid.

Workup

  1. customfor 8 hours
  2. custom15 minutes
  3. concentrationThe reaction mixture was concentrated in vacuo and purification of the residue by preparative LC-MS

Sources & evidence

ORD record
ord-779baf943ca849bd919c597570b84cf2
Source dataset
uspto-grants-2015_06
Patent number
US09056867B2

Reaction notes

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