Pyrazol-3-ylamine → 3-Amino-5-trifluoromethyl-pyrazine-2-carboxylic acid (2H-pyrazol-3-yl)-amide

HRID 2173708Notes

Reaction equation

HRID 2173708 reaction equation
FC(F)(F)[C:3]1[CH:4]=[C:5]([NH:8][C:9]([C:11]2[C:16]([NH2:17])=[N:15][C:14]([C:18]([F:21])([F:20])[F:19])=[C:13](Br)[N:12]=2)=[O:10])[NH:6][N:7]=1.NC1C(C(O)=O)=NC=C(C(F)(F)F)N=1.N1NC(N)=CC=1>>[N:7]1[NH:6][C:5]([NH:8][C:9]([C:11]2[C:16]([NH2:17])=[N:15][C:14]([C:18]([F:20])([F:21])[F:19])=[CH:13][N:12]=2)=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 74561Pyrazol-3-ylamineHCID 688182783-Amino-5-trifluoromethylpyrazine-2-carboxylic acid2×HCID 178508420HCID 178508420, compound

Product 1

HCID 715332663-Amino-5-trifluoromethyl-pyrazine-2-carboxylic acid (2H-pyrazol-3-yl)-amide

Procedure

The title compound was prepared analogously to 3-amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid (5-trifluoromethyl-2H-pyrazol-3-yl)-amide (Example 1) using 3-amino-5-trifluoromethyl-pyrazine-2-carboxylic acid (Intermediate 6) and 2H-pyrazol-3-ylamine.

Sources & evidence

ORD record
ord-04561543341240cfb0c0539187c69149
Source dataset
uspto-grants-2015_06
Patent number
US09056867B2

Reaction notes

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