Pyrazol-3-ylamine → 3-Amino-6-chloro-5-trifluoromethyl-pyrazine-2-carboxylic acid (2H-pyrazole-3-yl)amide

HRID 2173712Notes

Reaction equation

HRID 2173712 reaction equation
FC(F)(F)[C:3]1[CH:4]=[C:5]([NH:8][C:9]([C:11]2[C:16]([NH2:17])=[N:15][C:14]([C:18]([F:21])([F:20])[F:19])=[C:13](Br)[N:12]=2)=[O:10])[NH:6][N:7]=1.NC1C(C(O)=O)=NC([Cl:36])=C(C(F)(F)F)N=1.N1NC(N)=CC=1>>[N:7]1[NH:6][C:5]([NH:8][C:9]([C:11]2[C:16]([NH2:17])=[N:15][C:14]([C:18]([F:21])([F:20])[F:19])=[C:13]([Cl:36])[N:12]=2)=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 74561Pyrazol-3-ylamineHCID 894432623-Amino-6-chloro-5-trifluoromethyl-pyrazine-2-carboxylic acid2×HCID 178508420HCID 178508420, compound

Product 1

HCID 715333273-Amino-6-chloro-5-trifluoromethyl-pyrazine-2-carboxylic acid (2H-pyrazole-3-yl)amide

Procedure

The title compound was prepared analogously to 3-amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid (5-trifluoromethyl-2H-pyrazol-3-yl)-amide Example 1) using 3-amino-6-chloro-5-trifluoromethyl-pyrazine-2-carboxylic acid (Intermediate 7) and 2H-pyrazol-3-ylamine. The reaction was carried out using microwave radiation at 100° C. for 1 hour.

Workup

  1. customat 100° C.
  2. customfor 1 hour

Sources & evidence

ORD record
ord-8f772e9af1c044eeb464deddb3c077d3
Source dataset
uspto-grants-2015_06
Patent number
US09056867B2

Reaction notes

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