5-benzyl-1H-1,2,4-triazol-3-amine → HCID 178508422, compound

HRID 2173721Notes

Reaction equation

HRID 2173721 reaction equation
[NH2:1][C:2]1[C:3]([C:13]([OH:15])=O)=[N:4][C:5]([Br:12])=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1.[CH2:16]([C:23]1[N:27]=[C:26]([NH2:28])[NH:25][N:24]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[NH2:1][C:2]1[C:3]([C:13]([NH:28][C:26]2[NH:25][N:24]=[C:23]([CH2:16][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:27]=2)=[O:15])=[N:4][C:5]([Br:12])=[C:6]([C:8]([F:9])([F:10])[F:11])[N:7]=1

Participants

3

Reactant 2

HCID 11166975-benzyl-1H-1,2,4-triazol-3-amineHCID 58442296HCID 58442296, compound2×

Product 1

HCID 178508422HCID 178508422, compound

Procedure

The title compound was prepared analogously to Example 23 from 3-amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid (Intermediate 2) and 3-benzyl-1H-1,2,4-triazol-5-amine.

Sources & evidence

ORD record
ord-a6f69c67ec604ec4ad10028324113ed3
Source dataset
uspto-grants-2015_06
Patent number
US09056867B2

Reaction notes

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