Sodium Acetate → HCID 58442356, compound

HRID 2173725Notes

Reaction equation

HRID 2173725 reaction equation
[CH2:1]([O:3][C:4](=[O:10])[CH:5]([NH2:9])[C:6](=[NH:8])[NH2:7])[CH3:2].[CH:11]([C:13]([C:15]([F:18])([F:17])[F:16])=O)=O.C([O-])(=O)C.[Na+]>O>[CH2:1]([O:3][C:4]([C:5]1[C:6]([NH2:7])=[N:8][C:13]([C:15]([F:18])([F:17])[F:16])=[CH:11][N:9]=1)=[O:10])[CH3:2]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 27790243,3,3-Trifluoro-2-oxopropanalHCID 12439913HCID 12439913, compound

Product 1

HCID 58442356HCID 58442356, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of amino-carbamimidoyl-acetic acid ethyl ester (2 g, 9.22 mmol) and water (50 ml), a 20% aqueous solution of trifluoropyruvic aldehyde (2.32 g, 18.43 mmol) was added. To this mixture, sodium acetate (5.29 g, 64.52 mmol) was added (pH of the reaction mixture was pH5). The reaction mixture was left to stir at RT overnight. The resultant precipitate was filtered under vacuum purification by chromatography on silica eluting with iso-hexane:EtOAc (gradient of 0 to 10% EtOAc) afforded the title compound

Workup

  1. waitThe reaction mixture was left
  2. filtrationThe resultant precipitate was filtered under vacuum purification by chromatography on silica eluting with iso-hexane

Sources & evidence

ORD record
ord-cd0c7e0b4cc241e5b7d2e9b0a01e57ec
Source dataset
uspto-grants-2015_06
Patent number
US09056867B2

Reaction notes

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