HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 3-amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylate | HCID 86657667 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylic acid | HCID 58442311 | — |
Reaction Steps
To a stirring solution of ethyl 3-amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylate (300 mg, 0.990 mmol) in EtOH (10 ml), 2M NaOH (0.495 ml, 0.990 mmol) was added dropwise over 1 minute. After stirring at RT for 30 minutes the reaction mixture was poured into water (30 ml) and the pH was adjusted to pH 4 by addition of 1M HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09056867B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-3e85a89b27964d989b2d901f8d8a130c |
| Source note | uspto-grants-2015_06 |