Iodine → Methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate

Temperature

80 °C

2-Amino-4-trifluoromethyl-benzoic acid methyl ester, (48 g, 219 mmol) was dissolved in MeOH (750 ml). Silver sulfate (68.3 g, 219 mmol) and iodine (55.6 g, 219 mmol) was added and rinsed in with MeOH (50 ml). The reaction mixture was left for 1 hour at RT. The reaction mixture was filtered under vacuum and the filtrate concentrated in vacuo. The residue was taken up in MeOH (100 ml) and water (10 ml) and the mixture heated at 80° C. The crude solution was hot filtered to remove residual inorganics and the warm filtrate was poured slowly into water (750 ml) with vigorous stirring. The mixture was left to particulate for 10 minutes and filtered to give the title compound as an orange solid. MS m/z 345 [M+H]+.

1. washrinsed in with MeOH (50 ml)
2. filtrationThe reaction mixture was filtered under vacuum
3. concentrationthe filtrate concentrated in vacuo
4. filtrationThe crude solution was hot filtered
5. customto remove residual inorganics
6. additionthe warm filtrate was poured slowly into water (750 ml) with vigorous stirring
7. waitThe mixture was left
8. waitto particulate for 10 minutes
9. filtrationfiltered

ORD record

ord-9ab4b6385c7943dd8cc3e918aca08f63

Source dataset

uspto-grants-2015_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09056867B2