Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → Caspofungin Acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | L-Tyrosine | HCID 6057 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | n-{(2r,6s,9s,11r,12s,14As,15s,20s,23s,25as)-12-[(2-aminoethyl)amino]-20-[(1r)-3-amino-1-hydroxypropyl]-23-[(1s,2s)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1r)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1h-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide | HCID 2826718 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Methan(2H)ol | HCID 123113 | — |
| 생성물 | Caspofungin Acetate | HCID 6850808 | — |
반응 단계
By means of NMR the contents of caspofungin, ethanol, ethyl acetate and acetic acid were determined in the crystals obtained above as follows. Approximately 15 mg of sample and standard (DMB) were accurately weighed in a suitable vial. The samples were dissolved in MeOD by vortexing. The samples were measured at 600 MHz using a delay of 30 s at 300K. The spectra that were used for the calculation of the impurities in the aromatic region were measured using a delay of 5 s and 256 scans to enhance the signal to noise ratio. The analysis was carried out in duplo. Caspofungin was quantified using the tyrosine signal at 7.15 ppm. See Table 5 for results.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09056897B2 |
| 출처 데이터셋 | uspto-grants-2015_06 |
| ORD ID | ord-e39fd8ca65ae4faeabc33b9378de8bba |
| 출처 메모 | uspto-grants-2015_06 |