Water → HCID 178514872, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 4-hydroxy-3-phenylacetyl-1-(3-trifluoromethoxyphenyl)-1,8-naphthyridin-2(1H)-one (220 mg, 0.50 mmol) produced in Synthesis Example 1 in DMF (4 mL) was added hydrazine monohydrate (purity of 80%, 80 μL), and the mixture was stirred at 100 to 110° C. for 3 hours. To the reaction solution was added water. The resulting precipitate was separated by filtration, washed with water, and dried to give 3-benzyl-5-(3-trifluoromethoxyphenyl)-1H-pyrazolo[4,3-c][1,8]-naphthyridin-4(5H)-one as a form of crystal (204 mg, yield 94%).

Provenance & Evidence