Hydrazine hydrate (1:1) → HCID 178514867, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 4-hydroxy-1-phenyl-3-phenylacetyl-quinolin-2(1H)-one (255 mg, 0.72 mmol) produced in Synthesis Example 13 in DMF (7 mL) was added hydrazine monohydrate (purity of 80%, 0.12 mL), and the mixture was stirred at 100 to 110° C. for 4 hours. To the reaction solution was added a sodium hydrogencarbonate aqueous solution. The resulting precipitate was separated by filtration and dried to give 3-benzyl-5-phenyl-1H-pyrazolo[4,3-c]quinolin-4(5H)-one as a form of crystal (177 mg, yield 70%).

Provenance & Evidence